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Symbol Name ID |
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1 MGI:95613 |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | EEG with photoparoxysmal response |
EEG with spike-wave complexes |
Intellectual disability |
Epileptic encephalopathy |
Global developmental delay |
Focal impaired awareness seizure |
Generalized non-motor (absence) seizure |
Focal hemiclonic seizure |
Febrile seizure (within the age range of 3 months to 6 years) |
Atonic seizure |
Myoclonic seizure |
Status epilepticus |
| Disease(s) Associated with GABRA1 | ||||||||||||
| developmental and epileptic encephalopathy 19 |
| Mouse Phenotypes | increased susceptibility to pharmacologically induced seizures |
seizures |
myoclonus |
tonic-clonic seizures |
absence seizures |
abnormal spike wave discharge |
abnormal synapse morphology |
abnormal GABA-mediated receptor currents |
abnormal inhibitory postsynaptic currents |
abnormal miniature inhibitory postsynaptic currents |
decreased miniature inhibitory postsynaptic current amplitude |
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| Availability | Mouse Genotype | |||||||||||
| Gabra1tm1.1Geh/Gabra1tm1.1Geh | ||||||||||||
| Gabra1tm1.1Uru/Gabra1tm1.1Uru | ||||||||||||
| Gabra1tm1Twr/Gabra1tm1Twr | ||||||||||||
| Gabra1tm1.1Geh/Gabra1+ | ! | |||||||||||
| Gabra1tm1.1Mjga/Gabra1+ | ||||||||||||
| Gabra1tm2.1Geh/Gabra1+ | ||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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